abstract：OBJECTIVE:This study aims to uncover the regulatory effects of METTL3 on promoting the progression of prostate cancer (PCa) through N6-Methyladenosine (m6A) methylation on LEF1 mRNA. PATIENTS AND METHODS:The relative levels of METTL3 and LEF1 in 48 paired PCa tissues and adjacent ones were determined by quantitative R...

journal_title：European review for medical and pharmacological sciences

authors： Ma XX,Cao ZG,Zhao SL

更新日期：2020-04-01 00:00:00

abstract：OBJECTIVE:The aim of this study was to investigate the expression characteristics of LINC01857 in gastric cancer (GCa), and to further study whether it could promote GCa development by modulating microRNA-200b. PATIENTS AND METHODS:Quantitative Real Time-Polymerase Chain Reaction (qRT-PCR) was used to examine LINC0185...

journal_title：European review for medical and pharmacological sciences

authors： Chen GR,Sun W,Zheng K,Zhu W

更新日期：2020-04-01 00:00:00

abstract：OBJECTIVE:To illustrate the role of interleukin 6 (IL-6) in the progression of non-small cell lung cancer (NSCLC) via activating STAT1. PATIENTS AND METHODS:The level of IL-6 mRNA in 48 paired NSCLC tissues and matched normal ones was determined by quantitative Real Time-Polymerase Chain Reaction (qRT-PCR). Kaplan-Mei...

journal_title：European review for medical and pharmacological sciences

authors： Chen T,Li J,Zhou MH,Xu LJ,Pan TC

更新日期：2020-04-01 00:00:00

abstract：OBJECTIVE:The RIB43A domain with coiled-coils 2 (RIBC2) encodes an uncharacterized vertebrate protein exhibiting similarity with Chlamydomonas protofilament ribbon proteins, required for ciliary motility. To date, no functional variants capable of triggering a change in the expression of RIBC2 have been reported. PATI...

journal_title：European review for medical and pharmacological sciences

authors： Xiong M,Wang YY,Guo WW,Cai SW,Ning XY,Yang HY,Chen XW,Li B,Xu M

更新日期：2020-04-01 00:00:00

abstract：OBJECTIVE:This study aims to investigate whether PM2.5 exposure is involved in the induction of alveolar epithelial cell apoptosis and the progression of emphysema in mice, and to further explore its specific molecular mechanism. MATERIALS AND METHODS:A certain number of PM2.5 exposed mice and normal control mice were...

journal_title：European review for medical and pharmacological sciences

authors： Xu F,Xu A,Guo Y,Bai Q,Wu X,Ji SP,Xia RX

更新日期：2020-04-01 00:00:00

abstract：:No Abstract Available. ...

journal_title：European review for medical and pharmacological sciences

authors： Romano L,Bilotta F,Dauri M,Macheda S,Pujia A,De Santis GL,Tarsitano MG,Merra G,Di Renzo L,Esposito E,De Lorenzo A

更新日期：2020-04-01 00:00:00

abstract：OBJECTIVE:Colorectal cancer is a common malignant tumor of the digestive tract, and its incidence is closely related to lifestyle inheritance and colorectal adenoma. Circular RNA (circRNA) has been proved to participate in the progression of colorectal cancer cells. Our study aimed to investigate the function and the u...

journal_title：European review for medical and pharmacological sciences

authors： Zhang ZJ,Zhang YH,Qin XJ,Wang YX,Fu J

更新日期：2020-03-01 00:00:00

abstract：OBJECTIVE:Nasopharyngeal carcinoma (NPC) is a malignancy and is prone to distant metastasis and radioresistance. Long non-coding RNAs (lncRNAs) play vital roles in human cancers. The purpose of this study was to explore the role and the action mechanism of intergenic lncRNA (LINC00114) in NPC. MATERIALS AND METHODS:Th...

journal_title：European review for medical and pharmacological sciences

authors： Han YY,Liu K,Xie J,Li F,Wang Y,Yan B

更新日期：2020-03-01 00:00:00

abstract：OBJECTIVE:Glioma is characterized by high metastasis with poor outcomes. Long non-coding RNA metastasis associated lung adenocarcinoma transcript 1 (MALAT1) was well-explored in numerous human cancers, including glioma. This study aimed to provide a novel action mechanism of MALAT1 in glioma. MATERIALS AND METHODS:The...

journal_title：European review for medical and pharmacological sciences

authors： Ma R,Zhang BW,Zhang ZB,Deng QJ

更新日期：2020-03-01 00:00:00

abstract：OBJECTIVE:In this premarket clinical study, we evaluated the efficacy and safety of a novel Hydrogel (HYADD4-G) for reducing low back pain (LBP) in patients with degenerative disc disease (DDD). PATIENTS AND METHODS:Twenty-three patients with chronic LBP were enrolled. All patients presented with up to three lumbar bl...

journal_title：European review for medical and pharmacological sciences

authors： Mazza E,Marcia S,Mondaini F,Piras E,Giordan N,Torri T,Barbanti-Bròdano G,Parodi F

更新日期：2020-03-01 00:00:00

abstract：OBJECTIVE:The aim of this study was to clarify the role of microRNA-433-5p (miRNA-433-5p) in influencing pathological lesions following acute spinal cord injury (SCI) by targeting mitogen-activated protein kinase 1 (MAPK1). PATIENTS AND METHODS:SCI model was successfully established in mice by performing hitting injur...

journal_title：European review for medical and pharmacological sciences

authors： Zhou CL,Li F,Wu XW,Cong CL,Liu XD,Tian J,Zheng WZ,Yan JL

更新日期：2020-03-01 00:00:00

abstract：OBJECTIVE:Several long noncoding RNAs (lncRNAs) display functional effects in the tumorigenesis and progression of cervical cancer (CC). We aimed to investigate the roles of lncRNA tyrosine protein kinase transmembrane receptor 1 antisense RNA 1 (ROR1‑AS1) in the development of CC patients. PATIENTS AND METHODS:Revers...

journal_title：European review for medical and pharmacological sciences

authors： Zhang L,Yao HR,Liu SK,Song LL

更新日期：2020-03-01 00:00:00

abstract：OBJECTIVE:To screen the differentially expressed circular ribonucleic acids (circRNAs) related to gastric cancer and to explore their associations with the clinicopathological features of gastric cancer. PATIENTS AND METHODS:Cancer tissues of 50 gastric cancer patients undergoing surgical resection in our hospital fro...

journal_title：European review for medical and pharmacological sciences

authors： He YX,Ju H,Li N,Jiang YF,Zhao WJ,Song TT,Ren WH

更新日期：2020-03-01 00:00:00

abstract：OBJECTIVE:Triple-negative breast cancers (TNBC) are a subtype of breast cancer lacking of estrogen receptor (ER), progesterone receptor (PR), and human EGF-like receptor 2 (HER2). MiR-193 always acted as an oncogene and promoted toxic aldehyde accumulation and tyrosine hydroxylase dysfunction. The purpose of this study...

journal_title：European review for medical and pharmacological sciences

authors： Xu JH,Zhao JX,Jiang MY,Yang LP,Sun ML,Wang HW

更新日期：2020-03-01 00:00:00

abstract：OBJECTIVE:Among the genes involved in obesity, the Fat mass and obesity-associated gene (FTO) is certainly one of the most known and the relation between FTO rs9939609 and BMI is highly discussed; nevertheless, data about its influence on body composition are limited. MATERIALS AND METHODS:We carried out a study on a ...

journal_title：European review for medical and pharmacological sciences

authors： Merra G,Gualtieri P,Cioccoloni G,Falco S,Bigioni G,Tarsitano MG,Capacci A,Piccioni A,Costacurta M,Franceschi F,Di Renzo L

更新日期：2020-03-01 00:00:00

abstract：OBJECTIVE:To detect differentially expressed micro ribonucleic acids (miRNAs) in rats with myocardial ischemia/reperfusion (MIR), and to explore the influence of miR-19a on MIR rats and its mechanism. MATERIALS AND METHODS:Firstly, the Sprague-Dawley (SD) rats were used to prepare MIR models, RNAs were extracted, and ...

journal_title：European review for medical and pharmacological sciences

authors： Ma Z,Lan YH,Liu ZW,Yang MX,Zhang H,Ren JY

更新日期：2020-03-01 00:00:00

abstract：OBJECTIVE:On December 8, 2019, many cases of pneumonia with unknown etiology were first reported in Wuhan, China, subsequently identified as a novel coronavirus infection aroused worldwide concern. As the outbreak is ongoing, more and more researchers focused interest on the COVID-19. Therefore, we retrospectively anal...

journal_title：European review for medical and pharmacological sciences

authors： Lou J,Tian SJ,Niu SM,Kang XQ,Lian HX,Zhang LX,Zhang JJ

更新日期：2020-03-01 00:00:00

abstract：OBJECTIVE:To explore the relationship between micro ribonucleic acid (miR)-375 in regulating the N-Myc downstream-regulated gene 2 (Ndrg2)/interleukin-6 (IL-6)/signal transducer and activator of transcription 3 (STAT3) signaling pathway and diabetic retinopathy (DR) in rats. MATERIALS AND METHODS:Thirty Sprague- Dawle...

journal_title：European review for medical and pharmacological sciences

authors： Pu LJ,Chen W,Liu QH,Huang AP,Zhao Q,Gu HH

更新日期：2020-03-01 00:00:00

abstract：OBJECTIVE:The aim of this study was to determine the expression profile and the underlying mechanism of the long intergenic non-protein coding RNA AL161431.1 in EC (endometrial carcinoma). MATERIALS AND METHODS:In this study, the expression data for the lncRNA AL161431.1 in EC was downloaded from The Cancer Genome Atl...

journal_title：European review for medical and pharmacological sciences

authors： Gu ZR,Liu W

更新日期：2020-03-01 00:00:00

abstract：OBJECTIVE:This study aimed to clarify the impact of delayed adjuvant therapy on the outcome of HPV associated oropharyngeal squamous cell carcinoma (HPV-OPSCC). PATIENTS AND METHODS:A total of 157 patients with HPV-OPSCC treated by surgery and adjuvant radiotherapy or chemoradiation therapy were analyzed retrospective...

journal_title：European review for medical and pharmacological sciences

authors： Sievert M,Goncalves M,Mueller SK,Hecht M,Pflaum A,Grundtner P,Iro H,Gostian AO

更新日期：2020-02-01 00:00:00

abstract：OBJECTIVE:Accumulating studies have reported that circular RNAs (circRNAs) can act as novel prognostic biomarkers in multiple malignant tumors. Here, we conducted a study to investigate the potential function and molecular mechanism of action of hsa_circ_0010882 in gastric cancer (GC). PATIENTS AND METHODS:The express...

journal_title：European review for medical and pharmacological sciences

authors： Peng YK,Pu K,Su HX,Zhang J,Zheng Y,Ji R,Guo QH,Wang YP,Guan QL,Zhou YN

更新日期：2020-02-01 00:00:00

abstract：OBJECTIVE:Chordoma is a rare malignant tumor difficult to diagnose and treat. Long non-coding RNAs acting as novel biomarkers are frequently reported in numerous cancers. The purpose of this study was to investigate the role of long intergenic non-coding RNA 00662 (LINC00662) and its associated action mechanisms in cho...

journal_title：European review for medical and pharmacological sciences

authors： Wang CB,Wang Y,Wang JJ,Guo XL

更新日期：2020-02-01 00:00:00

abstract：OBJECTIVE:This study aimed to explore the role of miR-155-5p in middle cerebral artery occlusion/reperfusion (MCAO/R) model in rats and oxygen-glucose deprivation/reoxygenation (OGD/R)-induced SH-SY5Y cells. In addition, this study also aimed to explore the underlying mechanisms to expect that miR-155-5p may be investi...

journal_title：European review for medical and pharmacological sciences

authors： Shi Y,Li K,Xu K,Liu QH

更新日期：2020-02-01 00:00:00

abstract：OBJECTIVE:In this study, we investigated whether certain types of lipid profiles are major contributors of acute ischemic stroke (AIS). PATIENTS AND METHODS:We screened 13,285 hospitalized patients in two stroke medical centers treated with thrombolysis, thrombectomy, or conventional care for anterior cerebral artery-...

journal_title：European review for medical and pharmacological sciences

authors： Niu L,Jiang SW,Wang Y,Peng Y,Fei AH,Wang HR,Li Y,Zhang JC,Meaney C,Gao CJ,Pan SM

更新日期：2020-02-01 00:00:00

abstract：OBJECTIVE:We evaluated the effect of different concentrations of the esterase inhibitor, AEBSF, and acid treatment on acyl-ghrelin stability in human plasma samples subjected to a freeze/thaw cycle. MATERIALS AND METHODS:Four plasma samples were collected from each donor and treated with the following concentrations o...

journal_title：European review for medical and pharmacological sciences

authors： Deschaine SL,Leggio L

更新日期：2020-02-01 00:00:00

abstract：OBJECTIVE:To investigate the relationship between the meniscal defect area and OA progression and explore the effect and mechanism of SMSCs cell therapy in knee osteoarthritis (OA) rat model. MATERIALS AND METHODS:For animal experiments, knee osteoarthritis (OA) model was constructed in Sprague Dawley (SD) rats by rem...

journal_title：European review for medical and pharmacological sciences

authors： Qiong J,Xia Z,Jing L,Haibin W

更新日期：2020-02-01 00:00:00

abstract：OBJECTIVE:CircRNAs serve an essential role in regulating the development and progression of various tumors. The aim of this study was to examine the role and mechanism of circ_0009910 in hepatocellular carcinoma (HCC). MATERIALS AND METHODS:RT-qPCR was used to detect the expression of circ_0009910 and miR-335-5p in ti...

journal_title：European review for medical and pharmacological sciences

authors： Li HW,Liu J

更新日期：2020-02-01 00:00:00

abstract：OBJECTIVE:Multiple studies have unveiled that long non-coding RNAs (lncRNAs) contribute to oncogenesis. LncRNA ARAP1 antisense RNA 1 (ARAP1-AS1) has been demonstrated to serve as an oncogene in bladder tumor and colorectal cancer. This study attempted to explore the correlation of ARAP1-AS1 expressions with clinical pr...

journal_title：European review for medical and pharmacological sciences

authors： Jiang YH,Zhu XY,Guo ZY,Yang ZH

更新日期：2020-02-01 00:00:00

abstract：OBJECTIVE:The aim of this study was to investigate the role of long noncoding ribonucleic acids (lncRNAs) AK024094 in regulating the progression of breast cancer (BCa) and the potential mechanism. Our findings might help to provide a theoretical basis for the targeted therapy of BCa. PATIENTS AND METHODS:The relative ...

journal_title：European review for medical and pharmacological sciences

authors： Zheng TZ,Li YT,Li WJ

更新日期：2020-02-01 00:00:00

abstract：OBJECTIVE:Human infections with zoonotic coronavirus contain emerging and reemerging pathogenic characteristics which have raised great public health concern. This study aimed at investigating the global prevalence, biological and clinical characteristics of novel coronavirus, Wuhan China (2019-nCoV), Severe Acute Resp...

journal_title：European review for medical and pharmacological sciences

authors： Meo SA,Alhowikan AM,Al-Khlaiwi T,Meo IM,Halepoto DM,Iqbal M,Usmani AM,Hajjar W,Ahmed N

更新日期：2020-02-01 00:00:00

abstract：OBJECTIVE:Midazolam and sufentanil are common analgesic and sedative drugs, but the effects and mechanisms of the combination of these two drugs on pancreatitis injury have not been fully elucidated. MATERIALS AND METHODS:Rats pancreatitis model were randomly divided into 4 groups, model group, midazolam group, sufent...

journal_title：European review for medical and pharmacological sciences

authors： Zhou H,Zhu ZH,Liu Y,Liu YY

更新日期：2020-02-01 00:00:00

abstract：OBJECTIVE:To investigate the role and regulate the target of miRNA-411 on spinal cord injury. MATERIALS AND METHODS:The microglia cultured in vitro was activated by lipopolysaccharide (LPS) to express the inflammatory phenotype. The inflammatory response through miRNA-411 transfection in microglia was measured to cert...

journal_title：European review for medical and pharmacological sciences

authors： Sun F,Li SG,Zhang HW,Hua FW,Sun GZ,Huang Z

更新日期：2020-01-01 00:00:00

abstract：OBJECTIVE:Ovarian cancer (OC) is a common tumor in women, and the development of chemoresistance is the major obstacle to its treatment. Long non-coding RNAs (LncRNAs) have been linked to chemoresistance in many cancers. However, the function of lncRNA urothelial carcinoma associated1 (UCA1) in paclitaxel (PTX) resista...

journal_title：European review for medical and pharmacological sciences

authors： Li ZY,Wang XL,Dang Y,Zhu XZ,Zhang YH,Cai BX,Zheng L

更新日期：2020-01-01 00:00:00

abstract：OBJECTIVE:This study aims to illustrate the potential role of MAGI1-IT1 in the progression of non-small cell lung cancer (NSCLC) and the underlying mechanism. PATIENTS AND METHODS:The relative level of MAGI1-IT1 in normal lung tissues and NSCLC tissues was determined. Its level in NSCLC patients with different tumor s...

journal_title：European review for medical and pharmacological sciences

authors： Zhang G,Chen HX,Yang SN,Zhao J

更新日期：2020-01-01 00:00:00

abstract：OBJECTIVE:Long non-coding RNA (lncRNA) LINC00467 was found to be upregulated in glioma tissues by analyzing The Cancer Genome Atlas (TCGA) database. This study aims to uncover the biological role of LINC00467 in influencing the progression of glioma and to provide novel directions for clinical treatment of glioma. PAT...

journal_title：European review for medical and pharmacological sciences

authors： Jiang XH,Liu YY

更新日期：2020-01-01 00:00:00

abstract：OBJECTIVE:The aim of this study was to explore the influence of micro ribonucleic acid (miR)-29 on neuronal apoptosis in rats with cerebral infarction by regulating the protein kinase B (Akt) signaling pathway. MATERIALS AND METHODS:A total of 36 Sprague-Dawley rats were randomly divided into three groups, including: ...

journal_title：European review for medical and pharmacological sciences

authors： Rong W,Yang L,Li CY,Wu XT,Zhou ZD,Zhu WL,Yan Y

更新日期：2020-01-01 00:00:00

abstract：OBJECTIVE:LncRNAs play a key role in the development and progression of prostate cancer. In this study, the effects of the lncRNA BLACAT1 in prostate cancer were investigated. PATIENTS AND METHODS:Real-time PCR was used to detect the expression of BLACAT1 and miR-361 in prostate cancer tissues and adjacent normal tiss...

journal_title：European review for medical and pharmacological sciences

authors： Li HY,Jiang FQ,Chu L,Wei X

更新日期：2020-01-01 00:00:00

abstract：OBJECTIVE:The objective of this work is to compare cellular toxicity in vitro of two resins for orthodontic use: an auto-polymerizable composite and a photo-polymerizable composite. MATERIALS AND METHODS:Samples were obtained by joining a couple of steel orthodontic brackets by using auto-polymerizing or photo-polymer...

journal_title：European review for medical and pharmacological sciences

authors： Passarelli PC,Saccomanno S,De Angelis P,Romeo A,Piccirillo GB,Desantis V,Grippaudo C,D'Addona A

更新日期：2020-01-01 00:00:00

abstract：OBJECTIVE:The vital role of long noncoding RNAs (lncRNAs) in tumor progression has been identified in numerous studies. Nasopharyngeal carcinoma (NPC) is one of the most ordinary malignant tumors. This study aims to explore the role of lncRNA ROR1-AS1 in the metastasis of NPC. PATIENTS AND METHODS:Real Time-quantitati...

journal_title：European review for medical and pharmacological sciences

authors： Hou J,Yan J,Ren XY,Zhu K,Du XY,Li JJ,Xu M

更新日期：2020-01-01 00:00:00

abstract：OBJECTIVE:The aim of this study was to investigate the effects of microRNA-5195-3p (miR-5195-3p) on the proliferation of glioma cells and to explore its related mechanisms. PATIENTS AND METHODS:The expression level of miR-5195-3p in glioma tissues and cell lines was detected by quantitative Real Time-Polymerase Chain ...

journal_title：European review for medical and pharmacological sciences

authors： Yang J,Yan DM,Xhu LX,Si DM,Liang QH

更新日期：2020-01-01 00:00:00